
Why Endometriosis and Fibroids Often Show Up Together—And What That Means for You
How having both conditions can change your symptoms, your diagnosis, and your treatment plan

Living with endometriosis is never straightforward. Between the pain, the heavy periods, and the frustration of waiting for diagnosis or relief, you may already feel overloaded. But what if your symptoms could be caused by something else on top of endometriosis—something like uterine fibroids? You’re not alone in thinking it’s unfair, or even impossible, to have both. Yet, new evidence points to an unfortunate yet important truth: if you have endometriosis, you’re much more likely to also have uterine fibroids compared to other women.
Understanding this link could change how you—and your doctor—approach your care. Let’s look at what this means for your symptoms, your diagnosis, and the way forward.
Why Does It Matter If You Have Both Endometriosis and Fibroids?
Both endometriosis and uterine fibroids can significantly affect quality of life, particularly around the menstrual cycle. Because these conditions share many features, their symptoms often overlap, making it difficult to tell one from the other. Common issues include heavy or prolonged menstrual bleeding, painful periods, pelvic pressure or bloating, pain during intercourse, and difficulties with getting or maintaining a pregnancy.
If you’re suspicious that something else is behind your never-ending cramps or sudden changes in your bleeding patterns, knowing about this increased risk can help you get the answers—and treatment—you deserve.
How Common Is It to Have Both?
Recent research tells us that women with endometriosis are about three times more likely to have fibroids than women without endometriosis. To put it simply: if you have endometriosis, your chances of also having fibroids are significantly higher than you might expect.
That risk can be even greater. When researchers looked specifically at women with endometriosis compared to women who have no gynecological symptoms at all, they found women with endometriosis had up to seven times the odds of having fibroids.
Symptoms: When Should You Suspect Fibroids, Too?
It’s easy to dismiss new or changing symptoms as “just my endo," or the other way around in some cases in case you already know you have fibroids. But because endometriosis and fibroids often show up together, especially if you have a higher body mass index (BMI) or have had children, it’s important to pay attention if your symptoms change or worsen.
Some key changes can signal fibroids as well:
- Sudden increase in heavy or prolonged bleeding
- Worsening pelvic pressure or visible abdominal swelling
- Frequent urination or constipation, especially if you didn’t have those issues before
- Sudden changes in pain pattern
Not everyone will notice a dramatic shift. In fact, many women with both conditions end up undiagnosed or dismissed for years. If things feel different, advocate for yourself. Ask your healthcare provider: “Could I have fibroids, too?”
Struggling with Endometriosis and Fibroids?
Our specialists are here to help you understand your condition and explore your treatment options.
Get Expert HelpWhy Does This Happen? (And What Can You Do About It?)
Doctors aren’t entirely sure why endometriosis and fibroids so often go hand-in-hand. Both conditions depend on estrogen, but the exact overlap isn’t clear. Just like endometriosis, it is probably polygenic and multifactorial in the final analysis and we will eventually unravel that code. What the recent research does tell us, though, is that certain factors—like having a higher BMI—do make it more likely you’ll have both conditions.
Managing your BMI (aiming for a healthy weight) may help decrease your risk of developing fibroids. While you can’t control every risk factor, small steps toward a healthy lifestyle can make a difference, not just for your gynecological health but for your overall wellbeing.
How Does This Change Your Treatment Options?
If you have both endometriosis and fibroids, treatment can be more complicated—but also more tailored to your needs. Some approaches, like hormonal medications, may help both conditions. Others, like surgical removal of fibroids, might be necessary if symptoms are severe or impacting your fertility.
It’s crucial your doctor takes the possibility of both conditions into account when:
- Evaluating unexplained pelvic pain or heavy bleeding
- Discussing fertility treatments
- Planning surgery (to avoid missing hidden problems); compared to endo excision, myomectomies can be easier and demand a lesser skill set unless they are large or of certain configuration. With both, the required skill set is likely going to have to be at a higher level.
- Considering hormonal therapies
Missing one diagnosis can mean missing out on the most effective relief. That’s why awareness—yours and your doctor’s—matters.
Practical Takeaways: What to Ask and Watch For
Next time you’re talking with your healthcare provider—or even just tracking your symptoms—keep these points top of mind:
- Could my symptoms be caused by both endometriosis and fibroids?
- Should I have an ultrasound or MRI to check for fibroids if my bleeding or pain is getting worse?
- How might having both conditions influence my treatment options or fertility planning?
- What lifestyle changes could help lower my risk, especially regarding BMI?
- Are there warning signs I should watch for, like sudden rapid growth of my abdomen, severe changes in bleeding, or unmanageable pain?
The Practical Overview
Here’s what we don’t know yet: Having endometriosis doesn’t mean you’re guaranteed to get fibroids, or that you’ll suffer more. Odds ratios and risk numbers can’t predict what will happen to you as an individual. Some women with both conditions manage well with medication and self-care, while others may need more involved treatments.
And while recognizing the link between these conditions is crucial, don’t let statistics cause unnecessary anxiety—use this information to give yourself another tool for advocating for your health.
Other options like MRI, seeking a second opinion, or making lifestyle adjustments remain important if the answers you’re getting don’t add up with the way you feel.
References
Fiore A, Casalechi M, Sichenze L, Ferraro C, Magni B, Bellinghieri R, Vercellini P, Somigliana E, Viganò P, Salmeri N. Co-occurrence of endometriosis and uterine fibroids: a systematic review and meta-analysis. EClinicalMedicine. 2025 Sep 19;89:103510.. DOI: 10.1016/j.eclinm.2025.103510
Quick Answers
Which adenomyosis symptoms most affect daily life?
Adenomyosis symptoms that most disrupt quality of life usually come from two main issues: how the uterus bleeds and how it hurts. Many patients describe heavy or prolonged periods that interfere with work, school, travel, and sleep—sometimes with flooding, frequent pad/tampon changes, and fatigue that can follow significant blood loss. Severe period pain (often more than “normal cramps”) is also common, and it can feel deep, aching, or pressure-like, sometimes accompanied by an enlarged, tender uterus and a sense of pelvic heaviness or bloating.
Outside of the period itself, adenomyosis can contribute to chronic pelvic pain, pain with sex for some people, and bowel or bladder discomfort—especially when symptoms flare around the menstrual cycle. It can also overlap with endometriosis, and when both are present symptoms may intensify or become harder to tease apart. If your day-to-day life is being shaped by bleeding, pain, pressure, or fertility stress, our team can help you sort out whether adenomyosis, endometriosis, fibroids, or more than one condition may be driving the pattern—and what next-step options make sense for your goals.
Can endometriosis cause infertility and pelvic pain in your 20s?
Yes. Endometriosis can absolutely show up in your late 20s and it can be a driver of both chronic pelvic pain and fertility challenges. Pain can include severe or worsening period cramps, pain with sex, bowel or bladder pain, and “flare” patterns that track with your cycle—although symptom severity doesn’t always match how much disease is present.
Endometriosis can affect fertility in several ways, including adhesions that distort tubo‑ovarian anatomy, inflammation and immune signaling that interferes with fertilization or embryo development, and ovarian factors—especially when endometriomas are involved. For some patients, the uterine environment also matters, particularly when adenomyosis is present alongside endometriosis. In our practice, we focus on listening to your full symptom and fertility story and then building an evaluation that looks for endometriosis while also checking for common look‑alikes or coexisting issues, so we can tailor a plan to your goals—whether that’s pain relief, preserving fertility, or both.
Why does sex hurt more around my period?
Pain with sex that flares around your period often points to a hormonally driven pelvic pain source—meaning tissue and nerves in the pelvis become more inflamed and reactive in the days leading up to bleeding and during menstruation. Endometriosis is a common reason: lesions can irritate nearby nerves and organs, and the inflammatory chemicals they produce can amplify pain signals. Adenomyosis (endometrial-like tissue within the uterine muscle) can also make the uterus unusually tender and crampy, so penetration, orgasm-related uterine contractions, or even pelvic pressure can feel painful around that time.
The “where” and “when” of the pain matters. Deep pain with penetration can be related to endometriosis near the uterosacral ligaments, cervix/vaginal fornix, rectovaginal space, bowel, or bladder—especially if scarring or adhesions have altered how those structures move. Pain after sex or after orgasm can happen when pelvic floor muscles spasm or when uterine contractions tug on sensitized areas. If this pattern is recurring, our team can help map your symptom timing and triggers and evaluate for endometriosis, adenomyosis, pelvic floor dysfunction, and overlapping bladder/bowel involvement so treatment targets the real driver of your pain rather than just masking it.
Why is my period pain so severe it disrupts my daily life?
Severe, life-disrupting period pain isn’t “normal cramps,” and it often points to an underlying driver that deserves a real explanation—not just symptom masking. One common cause is endometriosis, where tissue similar to the uterine lining grows outside the uterus and can irritate pelvic structures, trigger inflammatory chemicals, and sometimes involve organs like the bowel or bladder. Another key point is that pain severity doesn’t reliably match “stage,” so someone can have intense pain even if imaging looks normal or disease appears limited.
When period pain is severe, worsening over time, starts years after your first period, or comes with heavy bleeding, painful sex, bowel pain with periods, urinary pain, or fatigue, we think in patterns—because endometriosis and related conditions can overlap with pelvic floor dysfunction, nerve pain/central sensitization, GI dysbiosis, vascular issues, or adenomyosis. Our approach is to take your full timeline and flare pattern seriously and then tailor evaluation with careful exam and expertly interpreted imaging when helpful. If your pain is disrupting school, work, relationships, or daily functioning, reach out to schedule a consultation—our team can help you identify what’s driving it and map out a plan aimed at lasting relief.
When is menstrual bleeding considered too heavy?
Menstrual flow is generally “too heavy” when it consistently disrupts your life or overwhelms your usual period products—think flooding or soaking through pads/tampons quickly, passing frequent or large clots, needing to double up, or bleeding long enough that you can’t plan around it. Another major clue is fatigue, dizziness, or shortness of breath that can come with iron deficiency from ongoing blood loss. If you’re timing your day around bathrooms, waking at night to change products, or avoiding work, exercise, travel, or sex because of bleeding, that’s not something we consider “normal.”
Heavy bleeding is a symptom, not a diagnosis, and common underlying drivers include adenomyosis, fibroids, hormonal imbalance, and sometimes endometriosis—especially when heavy bleeding shows up with severe cramps or deep pelvic pain. Because imaging and symptoms don’t always match (a scan can look “mild” while symptoms are intense), we take a symptom-led approach and look at the full pattern, including pain, pressure, clots, cycle timing, and any signs of anemia. If your bleeding feels like it’s escalating or you’ve been told to “just live with it,” our team can help you sort out likely causes and build a plan that targets the source—not just the bleeding.


